Quantitative analysis of signaling networks
نویسندگان
چکیده
منابع مشابه
Quantitative Analysis of Signaling Networks
Glioblastoma (GBM) is the most common malignant form of brain cancer. Even with treatment including surgery, radiation, and temozolomide chemotherapy, the 1 year survival rate is only 35%. To identify specific mediators of GBM progression in a genetically engineered murine model of proneural GBM, we quantified signaling networks using mass spectrometry. We identified oncogenic signaling associa...
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MOTIVATION Analysis of cellular signaling interactions is expected to pose an enormous informatics challenge, perhaps even larger than analyzing the genome. The complex networks arising from signaling processes are traditionally represented as block diagrams. A key step in the evolution toward a more quantitative understanding of signaling is to explicitly specify the kinetics of all chemical r...
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ژورنال
عنوان ژورنال: Progress in Biophysics and Molecular Biology
سال: 2004
ISSN: 0079-6107
DOI: 10.1016/j.pbiomolbio.2004.03.002